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説明
Serum amyloid A (SAA), a putative serum precursor of the AA protein which constitutes amyloid fibrils in secondary amyloidosis [l], has been clinically evaluated as one of the sensitive acute-phase reactants in serum [2,3]. The SAA concentration has been analyzed by radial i~unodiffusion (RID) f4,5] and radioi~unoassay (RIA) [6-81. The RID method was very simple and suitable for the analysis of SAA in its increased states, but could not determine the normal range of SAA because of low sensitivity. At present there are only a few descriptions outlining the use of enzyme immunoassay (EIA) in determining the concentration of SAA in serum [8,9]. It has also been mentioned that EIA may be unsuitable for this purpose because of poor reproducibility of results [S]. In this study, we attempted to develop a sensitive and highly reproducible EIA method for the measurement of SAA in serum, and to evaluate the normal range of the SAA.
収録刊行物
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- Clinica Chimica Acta
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Clinica Chimica Acta 179 169-175, 1989-02-01
Elsevier BV