A novel synthesis of 2‐arylaminothiazolo[4,5‐<i>d</i>]pyridazinones

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<jats:title>Abstract</jats:title><jats:p>The reaction of 5(4)‐amino‐4(5)‐chloropyridazin‐3(2<jats:italic>H</jats:italic>)‐ones <jats:bold>1 (9</jats:bold>) with methyl dithiocarbamates <jats:bold>2</jats:bold> gave 2‐arylaminothiazolo[4,5‐<jats:italic>d</jats:italic>]pyridazinones <jats:bold>3 (10</jats:bold>). Treatment of 5(4)‐alkylamino‐4(5)‐chloropyridazin‐3(2<jats:italic>H</jats:italic>)‐ones <jats:bold>5 (12</jats:bold>) with <jats:bold>2</jats:bold> afforded the corresponding 2‐aryliminothiazolo[4,5‐<jats:italic>d</jats:italic>]pyridazinones <jats:bold>6 (13</jats:bold>). Cyclization of <jats:bold>1a</jats:bold> with phenylisothiocyanate produced 2‐amino‐ and 2‐iminothiazolo[4,5‐<jats:italic>d</jats:italic>]pyridazinones <jats:bold>3a</jats:bold> and <jats:bold>16</jats:bold>.</jats:p>

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