Acridine derivatives. <b>V</b>. Synthesis and P388 antitumor activity of the novel 9‐anilino‐2,3‐ethylenedioxyacridines
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説明
<jats:title>Abstract</jats:title><jats:p>A new class of deoxyribonucleic acid (DNA)‐intercalating antitumor agents, novel 9‐anilino‐2,3‐ethylenedioxyacridines (five compounds) have been synthesized and evaluated for activity against P388 leukemia <jats:italic>in vivo.</jats:italic> A few of them possessed the same potency of antitumor activity as amsacrine (<jats:italic>m</jats:italic>‐AMSA) which is an important antitumor agent in clinical use.</jats:p>
収録刊行物
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- Journal of Heterocyclic Chemistry
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Journal of Heterocyclic Chemistry 30 1101-1104, 1993-07-01
Wiley