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説明
The effect of iodide on TSH-stimulated thyroid hormone release in the McKenzie bioassay was studied. When mice were given KI (0.01 or 10 mg/ml in drinking water) for 24 hr before TSH, thyroid 125I release in response to TSH expressed as the percent increase in serum 125I (2 hr value/0 hr value) was significantly inhibited, an effect in good agreement with previously reported results. However, the absolute increase in serum 125I (2 hr value-0 hr value) was not changed by Kl-treatment. In Kl-treated mice, the concentration of 125I present in the serum before TSH injection was significantly higher than that in the control mice. Methimazole (0.02 mg/ml in drinking water) abolished the inhibitory effect of iodide on the percent increase in serum 125I in response to TSH by abolishing the increase in the concentration of serum 125I before TSH. Changes in serum 125I-PBI were essentially the same as those in serum 125I. These results suggest that 1) the inhibitory effect of iodide on the percent increase in serum ...
収録刊行物
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- Endocrinology
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Endocrinology 93 532-539, 1973-09-01
The Endocrine Society
