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Description
The abnormalities of mutant haemoglobins Rainier and Bethesda hinge on the substitution of a vital tyrosine residue, which stabilizes the deoxy form of normal haemoglobin. Replacement of this tyrosine therefore results in high oxygen affinity and low co-operativity.
Journal
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- Nature New Biology
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Nature New Biology 235 70-72, 1972-01-01
Springer Science and Business Media LLC