Role of Penultimate Tyrosine in Haemoglobin β Subunit

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Description

The abnormalities of mutant haemoglobins Rainier and Bethesda hinge on the substitution of a vital tyrosine residue, which stabilizes the deoxy form of normal haemoglobin. Replacement of this tyrosine therefore results in high oxygen affinity and low co-operativity.

Journal

  • Nature New Biology

    Nature New Biology 235 70-72, 1972-01-01

    Springer Science and Business Media LLC

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