Biochemical studies on fibrosis of the liver and its prevention by using newly synthesized proline analogs

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1) Activities of collagenase-like peptidase and other enzymes were examined on cirrhotic or fibrous liver tissues, and that of Colg was found to be almost in parallel with oxyproline content in the liver tissues of human. But, s-gl activity was not high, when cirrhosis was completed. 2) Proline analogs synthesized for the prevention of fiber formation of the liver were tested against agar-induced granuloma and liver fibrosis experimentally induced in rats. 4-Amino proline or 4-amino-5-methyl proline seemed to be promising.

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