A RADIOAUTOGRAPHIC STUDY OF THE SYNTHESIS OF PHOSPHORUS COMPOUNDS IN CENTRAL NERVOUS TISSUES OF THE DOG

DOI PubMed

Search this article

Description

<jats:title>SUMMARY</jats:title><jats:p>Gross and microscopic radioautographic observations have been made on the sequential distribution of <jats:sup>32</jats:sup>P in the brain and spinal cord of the dog after intracisternal injection as orthophosphate.</jats:p><jats:p>There appear to be two stages in the process of <jats:sup>32</jats:sup>P incorporation into central nervous tissues. In the first, the phosphate in the CSF penetrates the central nervous tissue by diffusion. In the second, the phosphate is incorporated into various organic compounds in response to metabolic processes.</jats:p><jats:p>The chronological changes in intraneuronal <jats:sup>32</jats:sup>P localization indicate incorporation into cellular protein, RNA, DNA, and lipid and depend upon the turnover rate of <jats:sup>32</jats:sup>P in these fractions.</jats:p><jats:p>In the metabolism of phosphate the molecular layer of the cerebellum probably is involved only in rapid changes reflected by the acid‐soluble fraction. The cellular layers in addition are concerned with slower processes such as incorporation into structural compounds.</jats:p>

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top