Effects of a Dopamine Antagonist (Metoclopramide) on the Release of Beta-Endorphin, ACTH and Cortisol inHyperprolactinemic-Amenorrheic Women
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説明
Responses of LH, TSH, PRL, beta-endorphin-like immunoreactivity, ACTH and cortisol to metoclopramide were evaluated in hyperprolactinemic-amenorrheic women and normal women. Augmented TSH responses and blunted PRL responses to metoclopramide were found in hyperprolactinemic women compared to normal women. A significant increase in serum LH levels was found only in hyperprolactinemic women after metoclopramide. Thus, the hyperprolactinemic women showed hormonal changes compatible with increased central dopaminergic tone. A significant increase in circulating levels of beta-endorphin-like immunoreactivity, ACTH and cortisol was found in hyperprolactinemic women but not in normal women after metoclopramide administration. Thus, beta-endorphin and ACTH secretion appear to be tonically inhibited by increased central dopaminergic tone in hyperprolactinemic-amenorrheic women.
収録刊行物
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- Gynecologic and Obstetric Investigation
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Gynecologic and Obstetric Investigation 40 42-45, 1995-01-01
S. Karger AG