Erratum to: Effects of Anesthetic and Related Agents on Calcium-induced Calcium Release from Sarcoplasmic Reticulum Isolated from Rabbit Skeletal Muscle

Hiromi Katoh, Yutaka Kirino, Yoshinori Nozawa, Hiroyuki Shimonaka, Michio Yamamoto, Masaki Wakamatsu

doi:10.1007/bf03180325

We have investigated the effects of anesthetic and related agents on Ca2+-induced Ca2+ release (CICR) in heavy sarcoplasmic reticulum isolated from rabbit skeletal muscle. The purpose of this study is to elucidate their possible role as triggering agents in malignant hyperthermia (MH). None of the agents (ketamine, procaine, lidocaine, succinylcholine, pancuronium and fentanyl) affected CICR at clinical concentrations. At higher concentrations, procaine, pancuronium and succinylcholine inhibited CICR, but ketamine rather potentiated it. It is unlikely that lidocaine is a potent facilitator of CICR at any concentrations. We conclude that procaine, lidocaine, non-depolarizing muscle relaxants and opiate can be used safely for MH susceptible patients and that ketamine and succinylcholine are not recommended.

Erratum to: Effects of Anesthetic and Related Agents on Calcium-induced Calcium Release from Sarcoplasmic Reticulum Isolated from Rabbit Skeletal Muscle

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