Safety, Tolerability, and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis
この論文をさがす
説明
Among the many consequences of loss of CFTR protein function, a significant reduction of the secretion of bicarbonate (HCOTo evaluate the safety, tolerability, and effects of inhaled aerosols of NaHCOAn experimental, prospective, open-label, pilot, clinical study was conducted with 12 CF volunteer participants over 18 years of age with bronchiectasis and pulmonary functions classified as mildly to severely depressed. Sputum rheology, pH, and microbiology were examined as well as spirometry, exercise performance, quality-of-life assessments, dyspnea, blood count, and venous blood gas levels.Sputum pH increased immediately after inhalation of NaHCONebulized NaHCO
収録刊行物
-
- Clinical Drug Investigation
-
Clinical Drug Investigation 40 105-117, 2019-11-13
Springer Science and Business Media LLC
- Tweet
キーワード
- Adult
- Male
- Adolescent
- Cystic Fibrosis
- 610
- Pilot Projects
- Congenital
- Rare Diseases
- Clinical Research
- Administration, Inhalation
- Humans
- Pharmacology & Pharmacy
- Prospective Studies
- Lung
- Viscosity
- Sputum
- Pharmacology and Pharmaceutical Sciences
- Elasticity
- Sodium Bicarbonate
- Inhalation
- Administration
- Quality of Life
- Female