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Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson.
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Description
Keratoconus is a common ocular disorder that causes progressive corneal thinning and is the leading indication for corneal transplantation. Central corneal thickness (CCT) is a highly heritable characteristic that is associated with keratoconus. In this two-stage genome-wide association study (GWAS) of CCT, we identified a locus for CCT, namely STON2 rs2371597 (P = 2.32 × 10
Journal
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- Communications biology
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Communications biology 3 (1), 2019-11-10
Springer Nature
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Keywords
- Male
- Corneal Pachymetry
- Corneal diseases
- Epithelium, Corneal
- Keratoconus
- Genome-wide association studies
- Polymorphism, Single Nucleotide
- Cornea
- Corneal Transplantation
- Adaptor Proteins, Vesicular Transport
- Mice
- Gene Expression Regulation
- Computational platforms and environments
- Artificial Intelligence
- Animals
- Humans
- Female
- Genetic Predisposition to Disease
- Smad3 Protein
- Genome-Wide Association Study
Details 詳細情報について
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- CRID
- 1871710641494632320
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- HANDLE
- 2433/253548
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- ISSN
- 23993642
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- PubMed
- 32737415
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- Data Source
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- OpenAIRE