Pharmacology of ephedroxanes

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On the central nervous system, ephedrine showed intense stimulatory activities but pseudoephedrine mediated weaker influences, while ephedroxane and pseudoephedroxane exerted inhibitory actions. The effects of ephedroxane were generally intense as compared with those of pseudoephedroxane. On the autonomic nervous system, the ephedrines contracted vas deferens and potentiated the effect of norepinephrine, while the ephedroxanes elicited no contraction of vas deferens but potentiation of the action of norepinephrine in the catecholaminergic nervous system. In antihistamine and antibarium activity, the ephedrines elicited remarkable actions but the effects of the ephedroxanes were weak.

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