Inside Cover: Ir‐Catalyzed Asymmetric Hydrogenation of α‐Alkylidene β‐Lactams and Cyclobutanones (Chin. J. Chem. 7/2018)
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説明
<jats:p><jats:bold>The inside cover picture shows</jats:bold> Chiral β‐lactams and cyclobutanones are present in numerous natural and pharmaceutical products. A direct preparation of chiral four‐membered rings via metal‐catalyzed asymmetric hydrogenation has not been described yet. In this article, we report an Ir/BiphPHOX‐catalyzed asymmetric hydrogenation of α‐alkylidene β‐lactams and cyclobutanones for the direct preparation of β‐lactams and cyclobutanones bearing an α‐substituted stereocenter. Our tropos phosphine‐oxazoline biphenyl ligand is essential for the preparation of the desired products with high enantioselectivities. More details are discussed in the article by Zhang <jats:italic>et al.</jats:italic> on page 612–618. <jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/png" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/cjoc201880072-gra-0001-m.png"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p>
収録刊行物
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- Chinese Journal of Chemistry
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Chinese Journal of Chemistry 36 566-566, 2018-06-13
Wiley