Potential Anti-Tumor Promoting Activity of Lupane-Type Triterpenoids from the Stem Bark of<i>Glochidion zeylanicum</i>and<i>Phyllanthus flexuosus</i>
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説明
Four known lupane-type triterpenoids, glochidonol (1), glochidiol (2), lup-20(29)-ene-1beta,3beta-diol (3) and glochidone (3) were isolated from the stem bark of Glochidion zeylanicum. Previously, lupeol (5), lup-20(29)-ene-3beta,24-diol (6) and betulin (7) were isolated from the stem bark of Phyllanthus flexuosus. This study reports the assays of these lupane-type triterpenoids: all isolates 1-7 and synthetic analogues, glochidonyl acetate (1a), lup-20(29)-ene-1,3-dione (1b) and lup-20(29)-ene 3beta,24-diacetate (6a) were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA). Among them, the effects of compounds 2 (IC50 = 290 mol ratio/32 pmol TPA) and 3 (IC50 = 300) were stronger than the others. In addition, compound 2 exhibited a strong inhibitory effect on mouse skin tumor promotion in an in vivo mouse two-stage carcinogenesis test.
収録刊行物
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- Planta Medica
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Planta Medica 70 1234-1236, 2004-12-01
Georg Thieme Verlag KG
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キーワード
- Herpesvirus 4, Human
- Mice, Inbred ICR
- Skin Neoplasms
- Papilloma
- Plant Extracts
- 9,10-Dimethyl-1,2-benzanthracene
- Administration, Cutaneous
- Antineoplastic Agents, Phytogenic
- Triterpenes
- Specific Pathogen-Free Organisms
- Inhibitory Concentration 50
- Mice
- Phyllanthus
- Plant Bark
- Animals
- Tetradecanoylphorbol Acetate
- Female
- Antigens, Viral
- Phytotherapy
