Polymer‐supported bases, 4. Macrolide synthesis from ω‐bromocarboxylic acids using polymer‐supported 1,8‐diazabicyclo[5.4.0]undec‐7‐ene
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説明
<jats:title>Abstract</jats:title><jats:p>The macrolactonization of ω‐bromocarboxylic acids was carried out in the presence of polystyrene‐supported 1,8‐diazabicyclo[5.4.0]undec‐7‐ene. The macrolide yield was found to be a function of the degree of ring substitution and of crosslinking, which governs the effective concentration of the fixed substrate within the polymeric reagent. The effect of the polystyrene matrix on the macrolide yield in the heterogeneous system was discussed by comparison with the corresponding homogeneous reaction.</jats:p>
収録刊行物
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- Die Makromolekulare Chemie
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Die Makromolekulare Chemie 186 2473-2481, 1985-12-01
Wiley