Approach to Spirocyclohexadienes via Visible Light‐Mediated <i>ipso</i>‐Cyclization of Amino Acid Derivatives with <i>N</i>‐(2‐Phenyl)benzoyl Groups

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<jats:title>Abstract</jats:title><jats:p>Spirocycles are important structural motifs, found in natural and pharmaceutical compounds, which have attracted considerable interest in modern drug discovery research. Herein, we describe the development of a visible light‐mediated <jats:italic>ipso</jats:italic>‐cyclization of amino acid derivatives with <jats:italic>N</jats:italic>‐(2‐phenyl)benzoyl groups, allowing easy access to a variety of spirocyclohexadienes. The addition of water was found to be beneficial in promoting the reaction progress. Investigation of the substrate scope revealed that incorporating an electron‐donating moiety at the 3′‐position of the biphenyl group resulted in a more favorable outcome for spirocycle formation.</jats:p>

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