Comparative Study of the Sugar Chains of Alkaline Phosphatases Purified from Rat Liver and Rat AH–130 Hepatoma Cells
書誌事項
- タイトル別名
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- Occurrence of Fucosylated High–Mannose–Type and Hybrid–Type Sugar Chains
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説明
<jats:p>The N‐linked sugar chains of alkaline phosphatases, purified from rat AH‐130 hepatoma and from normal rat liver, were released quantitatively as oligosaccharides by hydrazinolysis and were labeled by reduction with NaB<jats:sup>3</jats:sup>H<jats:sub>4</jats:sub>. A comparative study of their structures revealed that the following structural differences are induced by hepatocyte carcinogenesis: complex–type tetraantennary sugar chains and hybrid–type sugar chains appear; outer‐chain moieties of the sugar chains of the hepatoma enzyme contain exclusively the Gal(β1‐4)GlcNAc groups (type 2 chains) but those of the normal enzyme contain other Gal(β1‐)GlcNAc groups and type 2 chains; and novel fucosylated high‐mannose‐type sugar chains are found in the oligosaccharides of the hepatoma enzyme.</jats:p>
収録刊行物
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- European Journal of Biochemistry
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European Journal of Biochemistry 236 579-590, 1996-03-01
Wiley