An Introduction to Liposome Encapsulation of Bioactive Polyanions
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<jats:title>Abstract</jats:title><jats:p>Polyanionic polymers with differing molecular weight, lipophilicity, and charge density were synthesized and their ability to non-specifically “activate” macrophages was evaluated. The level of activation of test polymer-elicited macrophages was monitored by their tumoricidal capacity. In addition, the ability of test polymers to inhibit growth of Lewis lung in vivo was evaluated. We have determined that the activation of macrophages by test polymers differs from that of the conventional activating agents pyran and C. parvum.</jats:p><jats:p>We then found that these polycarboxylic acid copolymers could be encapsulated by liposomes and administered intravenously. Superoxide production by murine peritoneal exudate macrophages activated by the test polyanions encapsulated in liposomes was increased by 300% in the first 2 hours compared to macrophages activated by the free polymers.</jats:p>
収録刊行物
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- MRS Proceedings
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MRS Proceedings 110 1987-01-01
Springer Science and Business Media LLC