この論文をさがす
説明
Abstract Susceptibility of T-cell-mediated cytotoxicity to X irradiation was examined in the stages of induction and expression. C3H/He mice and a methylcholanthrene-induced sarcoma of C57BL/6 origin were used for experiments. (i) Established cytotoxicity was radioresistant. (ii) Irradiation of hosts before tumor inoculation suppressed induction of cytotoxicity. Irradiation at 3 hr after tumor inoculation or later did not affect induction of cytotoxicity. (iii) Cytotoxicity became detectable on day 7 but not on day 3, when mice were irradiated 3 hr after tumor inoculation, (iv) Tumor resection abolished cytotoxicity when carried out 24 hr after tumor inoculation but not when carried out on day 3 or later. (v) Sonicated antigen of tumor cells proved to be effective in raising the radioresistant state in the hosts, since cytotoxicity was detectable in those given irradiation 3 hr and viable tumor cells 6 hr after the priming. The radioresistant nature of cytotoxicity may be acquired within a very short period after immunization. However, development of killer cells from such a radioresistant state requires further antigen stimulation with viable tumor cells for a limited period, and maturation of such cells requires some latent period thereafter.
収録刊行物
-
- Cellular Immunology
-
Cellular Immunology 25 228-236, 1976-08-01
Elsevier BV