Sulfated Hyaluronan coating of polyurethanebased implant materials
説明
<jats:title>Abstract</jats:title> <jats:p>Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubberlike properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.</jats:p>
収録刊行物
-
- Current Directions in Biomedical Engineering
-
Current Directions in Biomedical Engineering 6 446-449, 2020-09-01
Walter de Gruyter GmbH