Anti‐inflammatory activity and molecular mechanism of delphinidin 3‐sambubioside, a <i>Hibiscus</i> anthocyanin

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  • Takayuki Sogo
    Course of Biological Science and Technology, United Graduate School of Agricultural Science Kagoshima University Kagoshima Japan
  • Norihiko Terahara
    Department of Food Science and Technology, Faculty of Health and Nutrition Minami‐Kyushu University Miyazaki Japan
  • Ayami Hisanaga
    Course of Biological Science and Technology, United Graduate School of Agricultural Science Kagoshima University Kagoshima Japan
  • Takuma Kumamoto
    Course of Biological Science and Technology, United Graduate School of Agricultural Science Kagoshima University Kagoshima Japan
  • Takaaki Yamashiro
    Course of Biological Science and Technology, United Graduate School of Agricultural Science Kagoshima University Kagoshima Japan
  • Shusong Wu
    Course of Biological Science and Technology, United Graduate School of Agricultural Science Kagoshima University Kagoshima Japan
  • Kozue Sakao
    Course of Biological Science and Technology, United Graduate School of Agricultural Science Kagoshima University Kagoshima Japan
  • De‐Xing Hou
    Course of Biological Science and Technology, United Graduate School of Agricultural Science Kagoshima University Kagoshima Japan

書誌事項

公開日
2015-01-02
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/biof.1201
公開者
Wiley

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<jats:title>Abstract</jats:title><jats:p>Delphinidin 3‐sambubioside (Dp3‐Sam), a <jats:italic>Hibiscus</jats:italic> anthocyanin, was isolated from the dried calices of <jats:italic>Hibiscus sabdariffa</jats:italic> L, which has been used for folk beverages and herbal medicine although the molecular mechanisms are poorly defined. Based on the properties of Dp3‐Sam and the information of inflammatory processes, we investigated the anti‐inflammatory activity and molecular mechanisms in both cell and animal models in the present study. In the cell model, Dp3‐Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL‐6, MCP‐1, and TNF‐α induced by LPS. Cellular signaling analysis revealed that Dp3‐Sam and Dp downregulated NF‐κB pathway and MEK1/2‐ERK1/2 signaling. In animal model, Dp3‐Sam and Dp reduced the production of IL‐6, MCP‐1 and TNF‐α and attenuated mouse paw edema induced by LPS. Our <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> data demonstrated that <jats:italic>Hibiscus</jats:italic> Dp3‐Sam possessed potential anti‐inflammatory properties. © 2015 BioFactors, 41(1):58–65, 2015</jats:p>

収録刊行物

  • BioFactors

    BioFactors 41 (1), 58-65, 2015-01-02

    Wiley

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