Heterogeneity of antigens related to 7S domain of type IV collagen in serum: Application to patients with chronic liver disease
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説明
Several connective tissue components have been determined to evaluate hepatic fibrosis (l-51. The 7s collagen is the major cross-linking domain of type IV collagen and is not cleaved off during the assembly of the type IV collagen. Thus the serum concentration of the 7s collagen is one of the best measures for hepatic fibrosis [6]. Moreover, the serum concentration of the 7s collagen was elevated in proportion to the severity of liver disease and also to the progress of fibrosis [7]. The radioimmunoassay for 7s collagen is now based on the use of polyclonal antibody to the 7s domain of type IV collagen purified from human placenta [8]. The inhibition curves of control serum almost parallel that of the reference antigen. However, the heterogenity of the serum antigens related to 7S collagen is not clear in human samples, especially in liver disease. In the present study, the difference in antigenicity between the authentic 7s collagen and the cross-reacting material in human serum was carefully investigated using several samples representing different pathologies of the liver.
収録刊行物
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- Clinica Chimica Acta
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Clinica Chimica Acta 212 73-78, 1992-11-01
Elsevier BV