Catalytic asymmetric synthesis of propranolol and metoprolol using a La–Li–BINOL complex

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<jats:title>Abstract</jats:title><jats:p>The La–Li–(<jats:italic>R</jats:italic>)‐BINOL complex prepared from either lanthanum(III) chloride [LaCl<jats:sub>3</jats:sub> · 7H<jats:sub>2</jats:sub>O] or [La(O‐i‐Pr)<jats:sub>3</jats:sub>] has made possible effective catalytic asymmetric syntheses of therapeutically important ß‐blockers such as propranolol and metoprolol. The possible stereochemical course of asymmetric nitroaldol reactions has been also clarified.</jats:p>

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