Redistribution of cardiac output during exercise by functional mitral regurgitation in heart failure: compensatory O<sub>2</sub> peripheral uptake to delivery failure

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<jats:p> This is an analysis involving 134 heart failure patients with reduced ejection fraction versus 80 controls investigated during functional evaluation with gas exchange and hemodynamic, addressing the severe mitral regurgitation phenotype and testing the hypothesis that the backward cardiac output redistribution to the lung during exercise impairs delivery and overexpresses peripheral extraction. This information is new and has important implications in the management of heart failure. </jats:p>

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