Efficient generation of 2'-deoxyuridin-5-yl at 5'-(G/C)AAXUXU-3' (X = Br, I) sequences in duplex DNA under UV-irradiation
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説明
A highly sequence-specific photoreaction of 5'-(G/C)AA(X)U(X)U-3' was found by using 450-base pair DNA fragments containing (X)U under UV-irradiation (X = Br, I). The molecular basis of this high photoreactivity was investigated in detail using synthetic octanucleotides. Based on the experimental data, the mechanism for the efficient photoreaction was proposed.
収録刊行物
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- Nucleic Acids Symposium Series
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Nucleic Acids Symposium Series 48 19-20, 2004-11-01
Oxford University Press (OUP)