A case report of a renal transplant recipient developing chronic glomerular rejection with a weak antibody against anti‐donor T‐cell, only detected by flow‐cytometry crossmatch
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説明
<jats:p><jats:bold>Abstract: </jats:bold> The pathogenesis of antibody‐mediated rejection has been investigated, but the precise mechanism of chronic glomerular rejection remains unclear. We have followed the clinicopathological course of a patient with pre‐existing anti‐donor antibody only detected by flow‐cytometry crossmatch for over 3 years. Glomerular endothelial injuries and peculiar glomerular lesions were noted in biopsy specimen of postoperative year 3; however, both typical chronic vascular rejection lesions and peritubular capillary multilayered lesions were not revealed. We consider that the presence of weak anti‐donor antibody leading early onset of acute humoral rejection played a role in the pathogenesis of early onset of chronic transplant glomerulopathy.</jats:p>
収録刊行物
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- Clinical Transplantation
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Clinical Transplantation 17 36-40, 2003-06-01
Wiley