書誌事項
- タイトル別名
-
- <i>A Risk Factor for Atherosclerosis</i>
この論文をさがす
説明
<jats:p>Endothelial dysfunction by proinflammatory stimuli represents an important link between risk factors and the pathologic mechanisms underlying atherosclerosis. Thus, control of the inflammatory status of endothelial cells is crucial to limiting the disease. Tobacco smoking induces inflammatory reactions and promotes atherosclerosis; however, the mechanism that links cigarette smoking to an increased incidence of atherosclerosis is poorly understood. Our study demonstrates that acrolein, a known toxin in tobacco smoke, elevates oxidative stress via inactivation of thioredoxin reductase and stimulates expression of cyclooxygenase‐2 through activation of the protein kinase C, p38 mitogen‐activated protein kinase, and cAMP response element‐binding protein pathway in endothelial cells. Our finding suggests that acrolein may play a role in the progression of atherosclerosis.</jats:p>
収録刊行物
-
- Annals of the New York Academy of Sciences
-
Annals of the New York Academy of Sciences 1126 185-189, 2008-04-01
Wiley