Studies of pharmacological effects on pancreatic blood flow and its application to pancreatic angiography

Pancreat ic blood flow and its var ia t ions with drug adminis t ra t ion were measured in the anesthet ized dog by an e lect romagnet ic flowmeter. These findings were applied to improve angiographic visualizat ion of the pancreas. 1) T-shaped cannula provided with flowmeter was inserted into splenic, portal and super ior mesenter ic vein. Gastric b ranches of splenic vein and infer ior pancreatico-duodenal vein were ligated. By this preparat ions, total pancreatico-duodenal venous outflow was allowed to drain into portal circulat ion and was measured. Pancreat ic blood flow was obtained, deduct ing the duodenal fract ion from this value by the S6Rb clearance method (Delaney, J. P.: Circ. Res. 17 : 394, 1965). In 12 dogs, the average flow was 0 .77ml /m/gm. 2) Following int ravenous adminis t ra t ion of *secretin and **pancreozymin (each 1U/kg) , flow increased to peak (on an average, *164% and **129% of preadminis t ra t ion level) about 3 minutes a f te r and re turned to pread, level within about 15 minutes. 3) Following intra-celiac ar ter ia l adminis t ra t ion (ICAA) of *secretin and **pancreozymin (each 1 U/kg), flow increased to peak (on an average, *205% and **150% of pread, level) 1 ~ 2 minutes a f te r and re turned to pread, level within about 12 minutes. 4) In addition to these findings, constant pressure perfusion study and changes in venous 02 tension of the pancreas revealed tha t ICAA of secret in produced the most remarkable increase of capi l lary blood flow and per ipheral vascular di la tat ion of the pancreas. 5) In 5 celiac angiographies, ICAA of secret in (100U)2 minutes before cont ras t media inject ion have enhanced visual izat ion of small ar ter ies and parenchyma of the pancreas.