G1 phase-specific suppression of the Cdk2 activity by ginsenoside Rh2 in cultured murine cells
書誌事項
- 公開日
- 1996-11-01
- DOI
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- 10.1016/s0024-3205(96)00608-x
- 公開者
- Elsevier BV
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説明
Ginsenoside Rh2, a plant glycoside with a dammarane skeleton resembling a steroid skeleton as an aglycone, has anticancer potentials in vitro or in vivo. To elucidate the molecular mechanisms of the effects of Rh2, we have examined the Cyclin-dependent kinase-2 (Cdk2) activity in G1 arrested B16 melanoma cells and in S phase-arrested Meth-A sarcoma cells, that have been treated with Rh2. The kinase activity was suppressed in B16 cells but not in Meth-A cells. In addition, Rh2 was found to induce G1 arrest and concomitantly suppress the Cdk2 activity in carcinogen-susceptible BALB/c 3T3 A31-1-1 and A31-1-13 cell lines. Thus, Rh2 has a G1 phase-specific suppressive effect on the Cdk2 activity, supporting further evaluation of Rh2 and its related compounds in cancer chemoprevention studies.
収録刊行物
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- Life Sciences
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Life Sciences 60 PL39-PL44, 1996-11-01
Elsevier BV