Site-selective DNA hydrolysis by the combination of Ce(IV) and oligonucleotide bearing EDTA groups
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説明
By using appropriately modified oligonucleotides, a gap-structure is formed in substrate DNA, and 2-6 ethylenediamine-N,N,N'-triacetate residues are placed near this gap. When these composites are treated with homogenous Ce(IV)/EDTA complex, the phosphodiester linkages in the gap-site are selectively hydrolyzed at much greater rates than achieved previously by using unmodified oligonucelotides.
収録刊行物
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- Nucleic Acids Symposium Series
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Nucleic Acids Symposium Series 3 137-138, 2003-09-01
Oxford University Press (OUP)