On acute hypotensive effects of pindolol and propranolol in conscious rats
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説明
Abstract 1. 1. An acute hypotensive effect of pindolol or propranolol have been identified in conscious normotensive and experimental hypertensive rats. 2. 2. The hypotensive effect induced with pindolol (0.1 mg/kg i.p.) was slightly inhibited by lateral ventricle injection of 6-hydroxydopamine (6-OHDA), but that induced with propranolol (5 mg/kg i.p.) was not. 3. 3. These hypotensive effects were abolished by systemic administration of 6-OHDA (50 mg/kg i.v.) or by pretreatment with indomethacin (1 mg/kg i.p.).
収録刊行物
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- General Pharmacology: The Vascular System
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General Pharmacology: The Vascular System 11 213-219, 1980-01-01
Elsevier BV