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説明
The incidence of steroid-induced psychiatric syndromes averages about 5.7%, with a maximum incidence of 50% (Lewis and Smith 1983). Of the 55 anecdotal cases of steroid-induced psychiatric syndromes, 40% of patients manifested a depressive syndrome (Ling et al 1981). Thus, the incidence of depression induced by corticosteroids may be 2-20%. As for the treatment of steroid-induced depression, paradoxically, antidepressants have been reported to induce an exacerbation of agitation and psychosis (Hall et al 1979). Although lithium has been reported to show an antimanic effect with steroid-induced psychosis (Siegal 1978) as well as a prophylactic effect (Falk et al 1979), there have been few reports describing an antidepressant effect of lithium in steroid-induced depression. Previously, we reported 2 depressive patients with systemic lupus erythematosus (SLE) and cerebral infarction, while being treated with corticosteroid (Terao et al 1994). In both cases, lithium was remarkably effective and no severe side effects occurred. From these preliminary findings, we have hypothesized that lithium can be an effective treatment for steroid-induced depression. Two new cases are reported below that support this hypothesis.
収録刊行物
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- Biological Psychiatry
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Biological Psychiatry 41 1225-1226, 1997-06-01
Elsevier BV