Preventive effectiveness of MAO inhibitor and ineffectiveness of prothrombinopenic anticoagulant against increase in plasma thrombin activity by adrenaline, cholesterol, and traumatization
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説明
T he authors found that monoamine oxidase (MAO) inhibitors prevent powerfully the appearance of thrombosis induced experimentally by traumatization of the internal surface of blood vessels in rabbits without inhibiting extravascular clotting, and that they are much stronger than anticoagulants tested in such an experimental condition.rJ The authors3 also found that MAO inhibitors prevent the acute vascular reaction which is specifically induced by adrenaline in a dose of physiologic significance, but not in a large dose, or by cholesterol. The reaction consists of an acute edematous abnormality of the blood vessel wall, involving fractionation of elastic fibers and adherence of platelets and leukocytes to the endothelial surface, accompanied by a decrease in Moolten and Vromen’s adhesive platelet count as well as a shortening of the coagulation time of whole blood. In this experiment on rabbits the shortening of the one-stage prothrombin time induced by adrenaline5 or cholesterol6 or traumatization of the internal surface of blood vessels was subjected to testing of the preventive effect of phenindione, an anticoagulant, and of nialamide, a MAO inhibitor. It was found that nialamide prevents the shortening and that phenindione does not prevent it.
収録刊行物
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- American Heart Journal
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American Heart Journal 64 71-78, 1962-07-01
Elsevier BV