ACTION OF CHLORPROMAZINE ON THE RESPI‐RATORY SYSTEM OF GUINEA‐PIG BRAIN CELL‐FREE PREPARATIONS*
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<jats:title>Summary</jats:title><jats:p>The effects of chlorpromazine on respiration of guinea‐pig brain homogenates and mitochondrial preparations were studied.</jats:p><jats:p>Chlorpromazine exerts biphasic effect on cytochrome <jats:italic>c</jats:italic> oxidase system, inhibition and stimulation of oxygen uptake in high (over 10 ‐<jats:sup>4</jats:sup> M) and low (below 10<jats:sup>‐4</jats:sup> M) concentrations respectively.</jats:p><jats:p>Succinic dehydrogenase activity is also inhibited by chlarproma zine. Here the stimulatory effect of the drug has not been observed.</jats:p><jats:p>The inhibition of chlorpromazine on succinic dehydrogenase system can be protected and reactivated by several sulfhydryl reagents.</jats:p><jats:p>ATP alone does not restore the chlorpromazine‐inhibited enzyme activity (with pyruvate and fumarate as substrates), but if sulfhy dryl reagents co‐exist with ATP, significant restoration is observed. The suggestion was made that chlorpromazine may act on SH‐linkage of the respiratory enzymes.</jats:p>
収録刊行物
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- Psychiatry and Clinical Neurosciences
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Psychiatry and Clinical Neurosciences 10 354-363, 1957-03-01
Wiley