CenTauR: Toward a universal scale and masks for standardizing tau imaging studies
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- Victor L. Villemagne
- Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA
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- Antoine Leuzy
- Clinical Memory Research Unit Department of Clinical Sciences Lund University Malmö Sweden
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- Sandra Sanabria Bohorquez
- Genentech Inc. South San Francisco California USA
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- Santiago Bullich
- Life Molecular Imaging GmbH Berlin Germany
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- Hitoshi Shimada
- Department of Functional Brain Imaging National Institutes for Quantum and Radiological Science and Technology Chiba Japan
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- Christopher C. Rowe
- Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia
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- Pierrick Bourgeat
- Health and Biosecurity Flagship The Australian eHealth Research Centre CSIRO Brisbane Queensland Australia
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- Brian Lopresti
- Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania USA
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- Kun Huang
- Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia
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- Natasha Krishnadas
- Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia
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- Jurgen Fripp
- Health and Biosecurity Flagship The Australian eHealth Research Centre CSIRO Brisbane Queensland Australia
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- Yuhei Takado
- Department of Functional Brain Imaging National Institutes for Quantum and Radiological Science and Technology Chiba Japan
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- Alexandra Gogola
- Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania USA
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- Davneet Minhas
- Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania USA
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- Robby Weimer
- Genentech Inc. South San Francisco California USA
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- Makoto Higuchi
- Department of Functional Brain Imaging National Institutes for Quantum and Radiological Science and Technology Chiba Japan
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- Andrew Stephens
- Life Molecular Imaging GmbH Berlin Germany
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- Oskar Hansson
- Clinical Memory Research Unit Department of Clinical Sciences Lund University Malmö Sweden
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- Vincent Doré
- Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia
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<jats:title>Abstract</jats:title><jats:sec><jats:title>INTRODUCTION</jats:title><jats:p>Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale.</jats:p></jats:sec><jats:sec><jats:title>METHOD</jats:title><jats:p>One thousand forty‐five participants underwent tau scans with either <jats:sup>18</jats:sup>F‐flortaucipir, <jats:sup>18</jats:sup>F‐MK6240, <jats:sup>18</jats:sup>F‐PI2620, <jats:sup>18</jats:sup>F‐PM‐PBB3, <jats:sup>18</jats:sup>F‐GTP1, or <jats:sup>18</jats:sup>F‐RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauR<jats:sub>z</jats:sub>, was constructed.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>None of the regions known to display off‐target signal were included in the masks. The CenTauR<jats:sub>z</jats:sub> allows robust discrimination between low and high levels of tau deposits.</jats:p></jats:sec><jats:sec><jats:title>DISCUSSION</jats:title><jats:p>We constructed several tau‐specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://www.gaain.org/centaur-project">https://www.gaain.org/centaur‐project</jats:ext-link>.</jats:p></jats:sec>
収録刊行物
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- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 15 (3), 2023-07
Wiley