CenTauR: Toward a universal scale and masks for standardizing tau imaging studies

  • Victor L. Villemagne
    Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA
  • Antoine Leuzy
    Clinical Memory Research Unit Department of Clinical Sciences Lund University Malmö Sweden
  • Sandra Sanabria Bohorquez
    Genentech Inc. South San Francisco California USA
  • Santiago Bullich
    Life Molecular Imaging GmbH Berlin Germany
  • Hitoshi Shimada
    Department of Functional Brain Imaging National Institutes for Quantum and Radiological Science and Technology Chiba Japan
  • Christopher C. Rowe
    Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia
  • Pierrick Bourgeat
    Health and Biosecurity Flagship The Australian eHealth Research Centre CSIRO Brisbane Queensland Australia
  • Brian Lopresti
    Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania USA
  • Kun Huang
    Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia
  • Natasha Krishnadas
    Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia
  • Jurgen Fripp
    Health and Biosecurity Flagship The Australian eHealth Research Centre CSIRO Brisbane Queensland Australia
  • Yuhei Takado
    Department of Functional Brain Imaging National Institutes for Quantum and Radiological Science and Technology Chiba Japan
  • Alexandra Gogola
    Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania USA
  • Davneet Minhas
    Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania USA
  • Robby Weimer
    Genentech Inc. South San Francisco California USA
  • Makoto Higuchi
    Department of Functional Brain Imaging National Institutes for Quantum and Radiological Science and Technology Chiba Japan
  • Andrew Stephens
    Life Molecular Imaging GmbH Berlin Germany
  • Oskar Hansson
    Clinical Memory Research Unit Department of Clinical Sciences Lund University Malmö Sweden
  • Vincent Doré
    Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia

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<jats:title>Abstract</jats:title><jats:sec><jats:title>INTRODUCTION</jats:title><jats:p>Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale.</jats:p></jats:sec><jats:sec><jats:title>METHOD</jats:title><jats:p>One thousand forty‐five participants underwent tau scans with either <jats:sup>18</jats:sup>F‐flortaucipir, <jats:sup>18</jats:sup>F‐MK6240, <jats:sup>18</jats:sup>F‐PI2620, <jats:sup>18</jats:sup>F‐PM‐PBB3, <jats:sup>18</jats:sup>F‐GTP1, or <jats:sup>18</jats:sup>F‐RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauR<jats:sub>z</jats:sub>, was constructed.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>None of the regions known to display off‐target signal were included in the masks. The CenTauR<jats:sub>z</jats:sub> allows robust discrimination between low and high levels of tau deposits.</jats:p></jats:sec><jats:sec><jats:title>DISCUSSION</jats:title><jats:p>We constructed several tau‐specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://www.gaain.org/centaur-project">https://www.gaain.org/centaur‐project</jats:ext-link>.</jats:p></jats:sec>

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