Design of Au/SPIO composite nanoparticle for facile and biocompatible surface functionalization via Au–S bond
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説明
Immobilization of Au nanoparticles on super-paramagnetic iron-oxide (SPIO) enables facile and biocompatible surface functionalization via Au–S bond. Au/SPIO composite nanoparticle is easily modified by thiol-modified polyethylene glycol (PEG-SH), and they are successfully applied on MR tumor imaging. However, its large hydrodynamic size (~150 nm) still causes the accumulation to liver in vivo. In this study, we controlled the hydrodynamic size of Au/SPIO by testing different raw SPIOs and stabilizing polymers. As the best candidate, Au/Molday-ION which was synthesized from Molday-ION and polyvinyl alcohol comprised the hydrodynamic size of 56 nm. Moreover, PEGylated Au/Molday-ION showed excellent dispersibility in blood serum, with the hydrodynamic size of 65 nm. This surface functionalization strategy is effective for the constructions of magnetic nanocarriers for in vivo applications.
収録刊行物
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- Journal of Nanoparticle Research
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Journal of Nanoparticle Research 15 2012-12-05
Springer Science and Business Media LLC