Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1

DOI HANDLE PubMed Open Access

Description

Stem cell aging, characterized by elevated p16Biopsied muscles were analyzed at baseline and 24 h after squat exercise in 12 trained men (22 ± 2 y). Placebo (PLA) and immunostimulant Rg1 (5 mg) were supplemented 1 h before a squat exercise, using a double-blind counterbalanced crossover design.Perceived exertion at the end of resistance exercise session was significantly lowered after Rg1 supplementation. Exercise doubled endothelial progenitor cells (EPC) (EPC in skeletal muscle doubled 1 d after an acute bout of resistance exercise. The exercised effects in lowering EPC aging and tissue inflammation were enhanced by immunostimulant Rg1, suggesting the involvement of immune stimulation on EPC rejuvenation.

Journal

  • Aging

    Aging 13 16567-16576, 2021-06-28

    Impact Journals, LLC

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