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説明
<jats:title>ABSTRACT</jats:title><jats:p>The interaction between chlorpromazine (CPZ) and riboflavin binding protein (RBP) was studied by the spectrophotometric and spectrofluorometric methods.</jats:p><jats:p>CPZ combined with RBP in a 1:1 molar ratio and the dissociation constant was determined to be 3.8 × 10<jats:sup>–5</jats:sup>M at pH 7, 25°C. Flavins such as riboflavin (Rf) and lumiflavin were released from the complexes with RBP by the addition of CPZ. The mechanism of flavin‐release was mainly competitive binding between CPZ and a isoalloxazine ring of flavins to RBP.</jats:p><jats:p>The mechanism of some biological phenomena induced by CPZ was discussed based on the flavin‐CPZ interaction.</jats:p>
収録刊行物
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- The Journal of Dermatology
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The Journal of Dermatology 10 461-467, 1983-10-01
Wiley