The Gamna-Gandy body in cardiac myxoma

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The so-called Gamna-Gandy body is a sclerosiderotic granulomatous lesion composed of degenerate collagen fibers encrusted with iron and calcium. Only five cases of Gamna-Gandy body in the heart have been documented. We studied 7 patients with cardiac myxoma who underwent surgery in our university hospital, and Gamna-Gandy body was present in 3. All the Gamna-Gandy body-positive patients had ingested anticoagulant agents and/or antiplatelet drugs. These results suggest that the Gamna-Gandy body in cardiac myxoma is not a rare pathologic condition and that anticoagulant and/or antiplatelet therapy may have a causal relation to the pathogenesis of this lesion.

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