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説明
<jats:p>Histochemical observation was made to determine alkaline phosphatase (ALP) activity and its isoenzyme fractions on normal endometrium, endometrial hyperplasia and endometrial adenocarcinoma.</jats:p><jats:p>Normal endometrium showed a cyclic change in the ALP reaction during the phase of menstruation; the ALP reaction was positive in proliferative and early secretory phase but negative in late secretory phase. Normal endometrial ALP was thought to be one of the hormone‐dependent enzymes. Heat‐stable ALP fraction (HSAP) was not observed in normal endometrium.</jats:p><jats:p>All cases with endometrial hyperplasia showed a positive ALP reaction, and HSAP was observed in 8.3% of cystic glandular hyperplasia and 45.5% of adenomato us hyperplasia.</jats:p><jats:p>All cases with endometrial adenocarcinoma showed a positive ALP reaction. In general, well and moderately differentiated endometrial adenocarcinoma showed on strongly positive ALP reaction while a weakly positive ALP reaction was observed in poorly differentiated endometrial adenocarcinoma. It was suggested that the ALP reactivity of endometrial adenocarcinoma reflected the degrees of cell differentiation. HSAP was observed in 20% of endometrial adenocarcinoma.</jats:p><jats:p>The occurrence of HSAP was interpreted as the reversion of ALP to the placental ALP followed by endometrial carcinogenesis.</jats:p>
収録刊行物
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- Asia-Oceania Journal of Obstetrics and Gynaecology
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Asia-Oceania Journal of Obstetrics and Gynaecology 11 581-588, 1985-12-01
Wiley
