Degradation of thyroxine by the microsomal particles from rat liver

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Abstract 1. 1. Particles which catalyze the degradation of l -thyroxine labeled with 131 I at the 3′ and 5′ positions in the β-ring have been isolated from rat liver microsomes and purified. 2. 2. The reaction requires Fe 2+ and protein present in microsomal particles. 3. 3. Thyroxine degradation in the above reaction is correlated with lipid peroxide formation. It may be, therefore, that the microsomal protein functions with unsaturated fatty acids present in the particles as a prosthetic group for the oxidation or hydroxylation of the β-phenyl ring of thyroxine.

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