Tu1616 The Efficacy of Salvage Endoscopic Submucosal Dissection in Patients With Recurrent or Residual Tumor After Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

alcohol consumption, and complications such as incidence rates of hypotension (blood pressure, 90 mmHg), hypoxia (oxygen saturation, 93%), and bradycardia (heart rate, 50/min) were evaluated. Results: There were no cases of severe complications related to m-NLA. According to the ASA classification, patients were assigned to grade 1 (n 26), 2 (n 154), or 3 (n 9). Mean sedation time was 99.1 59.9 min. Regarding additional drugs, 66 patients (34.9%) required midazolam alone, 115 (60.8%) required midazolam and flunitrazepam, and 8 (4.2%) required midazolam, flunitrazepam, and haloperidol. The mean dose of midazolam and pethidine was 12.4 and 108.3 mg, respectively. Hypotension, hypoxia, and bradycardia occurred in 45 (23.8%), 160 (84.7%), and 6 (3.2%) patients, respectively. Regarding alcohol consumption, patients with everyday/occasional drinking required a mean midazolam dose of 12.0/12.9 mg, respectively. The number of drugs necessary for full sedation was significantly higher in patients with everyday drinking than in patients with occasional drinking (p 0.015). Conclusion: m-NLA with midazolam and pethidine is suggested to be useful for maintaining an appropriate sedation level, and is both feasible and safe in ESD for patients with SEC.