Clinical Experience of <sup>123</sup>I-IMP Scintigraphy in Detecting Vertebral Bone Metastases of Hepatocellular Carcinoma

DOI DOI PubMed Open Access

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  • A Comparison with Bone Scintigraphy with <sup>99m</sup>Tc-MDP

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<jats:p> Although bone scintigraphy with <jats:sup>99m</jats:sup>Tc-MDP is a sensitive diagnostic method to detect bone metastasis, it is not specific for malignancy. A radioactive substance which accumulates specifically into metastatic lesions should be of value. <jats:sup>123</jats:sup>I-IMP and bone scintigraphy with <jats:sup>99m</jats:sup>Tc-MDP were consecutively performed in patients with vertebral bone metastases from hepatocellular carcinoma and lumbar spondylosis deformans in a 7-day interval or shorter. The intensity of uptake was compared. Eighteen of the 20 metastatic lesions (90%) were classified as increased uptake areas in <jats:sup>123</jats:sup>I-IMP scintigraphy. MDP-scintigraphy disclosed 16 metastatic lesions (80%), 9 as “hot” lesions (56%) and 7 as “cold” lesions (44%). <jats:sup>123</jats:sup>I-IMP scintigraphy was negative in all 12 lesions of lumbar spondylosis deformans. Compared to MDP-scintigraphy, <jats:sup>123</jats:sup>I-IMP scintigraphy was more sensitive in detecting vertebral bone metastases of hepatocellular carcinoma with smaller rates of false-positive and false-negative findings. </jats:p>

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