PATHOLOGICAL STUDY ON AMYLOIDOSIS A NEW INDUCTION METHOD OF AMYLOIDOSIS TRYPAN BLUE*

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<jats:p>A high incidence of amyloidosis was induced in mice by repeated subcutaneous injection of trypan blue which lead to a disturbance of the reticulo‐ endothelial system.</jats:p><jats:p>In this series, the mode of amyloid deposition almost coincided with casein‐induced amyloidosis and differed from senile amyloidosis in mice.</jats:p><jats:p>As a possible mechanism of the occurrence of amyloidosis in this experiment, it was considered that dysfunction of reticulo‐endothelial cells was provoked by trypan blue‐injection and then amyloid was produced in these cells.</jats:p><jats:p>Our experiment provided an indirect evidence of cellular secretion of amyloid depending on reticulo‐endothelial cells.</jats:p>

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