SPORADIC BILATERAL PAPILLARY RENAL CARCINOMA EXHIBITING C-MET MUTATION IN THE LEFT KIDNEY TUMOR

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Papillary renal carcinoma is rare and has recently been recognized as a new clinicopathological subtype of human renal cell carcinoma. Hereditary papillary renal carcinoma is an inherited kidney cancer characterized by multiple and bilateral papillary renal carcinomas. Studies indicate that missense mutations of a c-met proto-oncogene lead to constitutive activation of c-met protein and contribute to tumorigenesis in a subset of sporadic papillary renal carcinoma. 1‐3 However, c-met mutations may be present at a low frequency and not detectable in small sets of papillary renal carcinomas. We report a case of sporadic bilateral papillary renal carcinoma with c-met protein over expression exhibiting missense mutation of a c-met proto-oncogene in only the left kidney tumor. CASE REPORT

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