PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites
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説明
lncRNA taurine-upregulated gene 1 (Tug1) is a promising therapeutic target in the progression of diabetic nephropathy (DN), but the molecular basis of its protection remains poorly understood. Here, we generate a triple-mutant diabetic mouse model coupled with metabolomic profiling data to interrogate whether Tug1 interaction with peroxisome proliferator-activated receptor gamma coactivator 1α (PGC1α) is required for mitochondrial remodeling and progression of DN in vivo. We find that, compared with diabetic conditional deletion of Pgc1α in podocytes alone (db/db; Pgc1α
収録刊行物
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- Cell Reports
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Cell Reports 36 109510-, 2021-01-01
Elsevier BV
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キーワード
- QH301-705.5
- Kidney
- Protective Agents
- lncRNA
- PGC1α
- Animals
- Urea
- Diabetic Nephropathies
- Biology (General)
- Mice, Knockout
- Arginase
- Podocytes
- diabetic nephropathy
- Tug1
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Mitochondria
- Mice, Inbred C57BL
- podocytes
- Disease Progression
- Metabolome
- RNA
- RNA, Long Noncoding
- Gene Deletion
