Sesquiterpene Glucosides from Anti-leukotriene B<sub>4</sub>Release Fraction of<i>Taraxacum Officinale</i>
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説明
Chemical examination of the MeOH extract of the root of Taraxacum officinale, which exhibited inhibitory activity on the formation of leukotriene B4 from activated human neutrophils, has resulted in the isolation of 14-O-beta-D-glucosyl-11,13-dihydro-taraxinic acid (1) and 14-O-beta-D-glucosyl-taraxinic acid (2). The absolute stereostructure of 1 has been established by X-ray chrystallographic examination.
収録刊行物
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- Journal of Asian Natural Products Research
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Journal of Asian Natural Products Research 3 191-197, 2001-07-01
Informa UK Limited
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キーワード
- Anti-HIV Agents
- Neutrophils
- Molecular Conformation
- Asteraceae
- Crystallography, X-Ray
- Leukotriene B4
- Plant Roots
- Structure-Activity Relationship
- Glucosides
- Japan
- Humans
- Nuclear Magnetic Resonance, Biomolecular
- Calcimycin
- Cells, Cultured
- Chromatography, High Pressure Liquid
- Inflammation
- Plants, Medicinal
- Dose-Response Relationship, Drug
- Molecular Structure
- Plant Extracts
- Stereoisomerism
- HIV-1
- Chromatography, Thin Layer
- Sesquiterpenes
- HeLa Cells
