Effects of prostaglandin E2 on adenosine-3',5'-monophosphate accumulation and progesterone synthesis in human corpora lutea In vitro

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Abstract Accumulation of adenosine-3',5'-monophosphate (cyclic AMP) and progesterone synthesis were studied in vitro in slices of human corpora lutea. On incubation of corpora lutea in vitro , prostaglandin E 2 (PGE 2 clearly stimulated progesterone synthesis, though its stimulatory effect was less than that of human chorionic gonadotropin (HCG). Conversely, accumulation of cyclic AMP induced by PGE 2 ; was markedly more than that induced by HCG. Exogenous cyclic AMP and dibutyryl cyclic AMP clearly stimulated progesterone synthesis. The present data suggest that the mechanism of action of PGE 2 on the human corpus luteum in vitro may be mediated by cyclic AMP

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