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Genotype Frequencies of the Human Platelet Antigen, Ca/Tu, in Japanese, Determined by a PCR‐RFLP Method
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Description
<jats:title>Abstract</jats:title><jats:p>Recently, the polymorphism of a new human platelet antigen, Ca/Tu, was shown to be derived from a G‐A nucleotide substitution at base 1564 of GPIIIa cDNA, which leads to a single amino acid difference, Arg/Gln at amino acid 489 of GPIIIa. We developed a PCR‐RFLP method to determine the genotypes of Ca/Tu and their frequencies in a Japanese population. Fifteen Ca/Tu<jats:sup>a</jats:sup> donors comprising 1 Ca/Tu(a/a) homozygous donor and 14 Ca/Tu(a/b) heterozygous donors were found among the 314 random donors analyzed. The frequencies of Ca/Tu genes were 0.025 (Ca/Tu<jats:sup>a</jats:sup>) and 0.975 (Ca/Tu<jats:sup>b</jats:sup>). The present study showed that the frequency of Ca/Tu<jats:sup>a</jats:sup> individuals in the Japanese (15/314) was approximately 7‐fold higher than in the Finnish population (1/150) previously reported by Kekomäki et al. Therefore, attention must be given to the involvement of the Ca/Tu alloantigen in neonatal alloimmune thrombocytopenia and the refractoriness of platelet transfusion.</jats:p>
Journal
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- Vox Sanguinis
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Vox Sanguinis 70 40-44, 1996-01-01
Wiley