Continuous Production of<i>N</i>-(Benzyloxycarbonyl)-L-Glycyl-L-Phenylalanine Methyl Ester Utilizing Extractive Reaction in Aqueous/Organic Biphasic Medium

T. Oda, Yoshihiko Murakami, Akira Hirata, K. Chiba

doi:10.1080/10826060008544940

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Continuous Production of<i>N</i>-(Benzyloxycarbonyl)-L-Glycyl-L-Phenylalanine Methyl Ester Utilizing Extractive Reaction in Aqueous/Organic Biphasic Medium

DOI PubMed

T. Oda
Yoshihiko Murakami
Akira Hirata
K. Chiba

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説明

N-(Benzyloxycarbonyl)-L-glycyl-L-phenylalanine methyl ester was continuously synthesized, enzymatically, utilizing an extractive reaction in an aqueous/organic biphasic system. The extremely high yield, ca. 100%, was obtained continuously in a water/butyl acetate biphasic medium.